HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chlorine → HCID 178448329, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chlorine | HCID 24526 | — |
| Reactant | 3-Pyrroline | HCID 66059 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | HCID 178448337 | HCID 178448337 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | Dichloromethane ethanol | HCID 21584144 | — |
| Product | HCID 178448329 | HCID 178448329 | 64% |
Reaction Steps
Prepared analogously to Example 1g from (1S)-3-trifluoromethyl-4-{N-[1-(5-chloro-1H-benzimidazol-2-yl)butyl]aminocarbonyl}benzoic acid, TBTU, diisopropylethylamine, and 3-pyrroline in tetrahydrofuran. Yield: 64%; Rf value: 0.47 (silica gel: dichloromethane/ethanol=9:1); C24H22ClF3N4O2 (490.911); mass spectrum: (M+H)+=491/493 (chlorine isotope).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07326791B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-f1f336fde4f54799bf2c4ea04deb31f7 |
| Source note | uspto-grants-2008_02 |