Water → HCID 178427183, compound

Participants

Reaction Steps

130 mg (0.22 mmol) of N-[(1S)-1-(5-chloro-1H-benzimidazol-2-yl)-3-(3-chloropropylsulfonylamino)propyl]-3-methyl-4-(pyrrolidin-1-ylcarbonyl)benzamide is dissolved in 5 mL of dimethylformamide and, after the addition of 21 mg (0.45 mmol) of sodium hydride (50% in oil), stirred for 2 hours at ambient temperature. Then it is combined with water and extracted with ethyl acetate. The combined organic extracts are dried over sodium sulfate and concentrated by evaporation. Yield: 90 mg (70%); Rf value: 0.40 (silica gel: dichloromethane/ethanol=9:1); C26H30ClN5O4S (544.077); mass spectrum: (M+H)+=545/547 (chlorine isotope).

Provenance & Evidence