HuagongsheHuagongshe Chemistry Print Report · For research reference only
BROMINE CHLORIDE (BrCl) → HCID 178467901, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | BROMINE CHLORIDE (BrCl) | HCID 61697 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | 3-Bromo-4-(2,5-dihydropyrrol-1-ylcarbonyl)benzoic acid | HCID 69309865 | — |
| Reactant | HCID 178467900 | HCID 178467900 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | Dichloromethane ethanol | HCID 21584144 | — |
| Product | HCID 178467901 | HCID 178467901 | 32% |
Reaction Steps
Prepared analogously to Example 1g from 3-bromo-4-(2,5-dihydropyrrol-1-ylcarbonyl)benzoic acid, TBTU, diisopropylethylamine and (1R)-1-(5-chloro-1H-benzimidazol-2-yl)-2-ethoxyethylamine in tetrahydrofuran. Yield: 32%; Rf value: 0.5 (silica gel: dichloromethane/ethanol=9:1); C23H22BrClN4O3 (517.809); mass spectrum: (M+H)+=517/519/521 (bromo-chlorine isotope).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07326791B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-a333df7fa2d244baa8d6ea792fd289c3 |
| Source note | uspto-grants-2008_02 |