HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chlorine → 3-chloro-N-[(1S)-1-(5-chloro-1H-benzimidazol-2-yl)ethyl]-4-(4,5,6,7-tetrahydroindol-1-yl)benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chlorine | HCID 24526 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | HCID 22609213 | HCID 22609213 | — |
| Reactant | (S)-1-(5-chloro-1H-benzimidazol-2-yl)ethylamine | HCID 42034613 | — |
| Reactant | 3-Chloro-4-(4,5,6,7-tetrahydroindol-1-yl)benzoic acid | HCID 69315270 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 3-chloro-N-[(1S)-1-(5-chloro-1H-benzimidazol-2-yl)ethyl]-4-(4,5,6,7-tetrahydroindol-1-yl)benzamide | HCID 178462085 | 25% |
Reaction Steps
Prepared analogously to Example 1g from 3-chloro-4-(4,5,6,7-tetrahydroindol-1-yl)benzoic acid, TBTU, diisopropylethylamine, and (1S)-1-(5-chloro-1H-benzimidazol-2-yl)ethylamine in tetrahydrofuran. Yield: 25%; Rf value: 0.90 (silica gel: dichloromethane/ethanol/ammonia=4:1:0.1); C24H22C12N4O (453.371); mass spectrum: (M+H)+=453/455/457 (chlorine isotope).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07326791B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-b81cc26f6e4c49a0b6d8e6a6df630c4a |
| Source note | uspto-grants-2008_02 |