HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chlorine → Rac.-n-[1-(5-chloro-1h-indol-2-yl)ethyl]-3-methyl-4-(pyrrolidin-1-ylcarbonyl)benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chlorine | HCID 24526 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | 3-Methyl 4-(pyrrolidin-1-ylcarbonyl)benzoic acid | HCID 12068686 | — |
| Reactant | HCID 22609213 | HCID 22609213 | — |
| Reactant | 1-(5-Chloro-1h-indol-2-yl)ethan-1-amine | HCID 65334165 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | Rac.-n-[1-(5-chloro-1h-indol-2-yl)ethyl]-3-methyl-4-(pyrrolidin-1-ylcarbonyl)benzamide | HCID 59655324 | 95% |
Reaction Steps
Prepared analogously to Example 1g from 3-methyl-4-(pyrrolidin-1-ylcarbonyl)benzoic acid, TBTU, diisopropylethylamine, and rac.-1-(5-chloro-1H-indol-2-yl)ethylamine in tetrahydrofuran. Yield: 95%; Rf value: 0.65 (silica gel: dichloromethane/ethanol/ammonia=9:1:0.1); C23H24ClN3O2 (409.915); mass spectrum: (M+H)+=410/412 (chlorine isotope).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07326791B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-cbdac1b4b729441b84fb097bcfda02d9 |
| Source note | uspto-grants-2008_02 |