HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydrofuran → HCID 59655270, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Chlorine | HCID 24526 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | HCID 69312462 | HCID 69312462 | — |
| Reactant | 3-Chloro-4-(2,5-dihydropyrrol-1-ylcarbonyl)benzoic acid | HCID 69315164 | — |
| Solvent | Dichloromethane ethanol | HCID 21584144 | — |
| Product | HCID 59655270 | HCID 59655270 | — |
Reaction Steps
Prepared analogously to Example 1g from 3-chloro-4-(2,5-dihydropyrrol-1-ylcarbonyl)benzoic acid, TBTU, diisopropylethylamine, and rac.-(5-chloro-1H-indol-2-yl)phenylmethylamine in tetrahydrofuran. Yield: 42%; Rf value: 0.58 (silica gel: dichloromethane/ethanol=95:5); C27H21Cl2N3O2 (490.388); mass spectrum: (M+H)+=490/492/494 (chlorine isotope).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07326791B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-83dec60182ea41bbaef2e423108d6c21 |
| Source note | uspto-grants-2008_02 |