HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chlorine → HCID 69312350, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chlorine | HCID 24526 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | 2-(5-chloro-1H-indol-2-yl)acetic acid | HCID 20454075 | — |
| Reactant | HCID 69312601 | HCID 69312601 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | Dichloromethane ethanol | HCID 21584144 | — |
| Product | HCID 69312350 | HCID 69312350 | 37% |
Reaction Steps
Prepared analogously to Example 1g from 2-(5-chloro-1H-indol-2-yl)acetic acid, TBTU, diisopropylethylamine, and 3-chloro-4-(2,5-dihydropyrrol-1-ylcarbonyl)phenylamine in tetrahydrofuran. Yield: 37%; Rf value: 0.34 (silica gel: dichloromethane/ethanol=95:5); C21H19Cl2N3O2 (416.306); mass spectrum: (M+H)+=416/418 (chlorine isotope).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07326791B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-d5b8752a7185460c9fd3b08f01d62fae |
| Source note | uspto-grants-2008_02 |