HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 4-(4-Oxo-2-propyl-4,5-dihydroimidazo[4,5-c]pyridin-1-yl)-3-trifluoromethylbenzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Dichloromethane methanol | HCID 21226129 | — |
| Reactant | 4-(4-Oxo-2-propyl-4,5-dihydroimidazo[4,5-c]-pyridin-1-yl)-3-trifluoromethylbenzonitrile | HCID 69311353 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 4-(4-Oxo-2-propyl-4,5-dihydroimidazo[4,5-c]pyridin-1-yl)-3-trifluoromethylbenzoic acid | HCID 69312597 | 98% |
Reaction Steps
Prepared analogously to Example 1f from 4-(4-oxo-2-propyl-4,5-dihydroimidazo[4,5-c]-pyridin-1-yl)-3-trifluoromethylbenzonitrile and sodium hydroxide solution in ethanol. Yield: 98%; Rf value: 0.42 (silica gel: dichloromethane/methanol/glacial acetic acid=4:1:0.1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07326791B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-2a6944a944a243689b0274c268cd396d |
| Source note | uspto-grants-2008_02 |