HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chlorine → HCID 178432303, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chlorine | HCID 24526 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | (S)-1-(5-chloro-1H-benzimidazol-2-yl)ethylamine | HCID 42034613 | — |
| Reactant | 4-(2-Methyl-4,5,6,7-tetrahydrobenzimidazol-1-yl)-3-trifluoromethylbenzoic acid | HCID 69315423 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 178432303 | HCID 178432303 | 45% |
Reaction Steps
Prepared analogously to Example 1d from 4-(2-methyl-4,5,6,7-tetrahydrobenzimidazol-1-yl)-3-trifluoromethylbenzoic acid, PFTU, diisopropylethylamine, and (1S)-1-(5-chloro-1H-benzimidazol-2-yl)ethylamine in dimethylformamide. Yield: 45%; C25H23ClF3N5O (501.938); mass spectrum: (M−H)−=500/502 (chlorine isotope).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07326791B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-f7209d8b465d49c49e6558d3a1895c22 |
| Source note | uspto-grants-2008_02 |