HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chlorine → HCID 178464816, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chlorine | HCID 24526 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | (3-oxopiperazin-2-yl)acetic acid | HCID 4777784 | — |
| Reactant | HCID 178464831 | HCID 178464831 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 178464816 | HCID 178464816 | 32% |
Reaction Steps
Prepared analogously to Example 1d from rac.-2-chloro-4-{N-[1-(5-chloro-1H-benzimidazol-2-yl)ethyl]aminocarbonyl}benzoic acid, PFTU, diisopropylethylamine, and 3-(hydroxycarbonylmethyl)piperazin-2-one in dimethylformamide. Yield: 32%; C23H21Cl2N5O5 (518.355); mass spectrum: (M+H)+=518/520/522 (chlorine isotope).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07326791B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-49d1801365fc4c5f80700f7ed2a57b87 |
| Source note | uspto-grants-2008_02 |