HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chlorine → HCID 178462096, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chlorine | HCID 24526 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | (S)-1-(5-chloro-1H-benzimidazol-2-yl)ethylamine | HCID 42034613 | — |
| Reactant | HCID 69311361 | HCID 69311361 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | HCID 178462096 | HCID 178462096 | 51% |
Reaction Steps
Prepared analogously to Example 1g from 4-(4-oxo-4,5-dihydroimidazo[4,5-c]pyridin-1-yl)-3-trifluoromethylbenzoic acid, TBTU, diisopropylethylamine, and (1S)-1-(5-chloro-1H-benzimidazol-2-yl)ethylamine in dimethylsulfoxide. Yield: 51%; Rf value: 0.16 (silica gel: dichloromethane/methanol=10:1); C23H16ClF3N6O2 (500.866); mass spectrum: (M+H)+=501/503 (chlorine isotope).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07326791B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-e81aef95ac6847438da48896194fa74a |
| Source note | uspto-grants-2008_02 |