HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chlorine → HCID 178432304, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chlorine | HCID 24526 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | (S)-1-(5-chloro-1H-benzimidazol-2-yl)ethylamine | HCID 42034613 | — |
| Reactant | HCID 69309862 | HCID 69309862 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 178432304 | HCID 178432304 | 35% |
Reaction Steps
Prepared analogously to Example 1d from 3-chloro-4-(2-methyl-4,5,6,7-tetrahydrobenzimidazol-1-yl)benzoic acid, PFTU, diisopropylethylamine, and (1S)-1-(5-chloro-1H-benzimidazol-2-yl)ethylamine in dimethylformamide. Yield: 35%; C24H23Cl2N5O (468.386); mass spectrum: (M+H)+=466/468/470 (chlorine isotope).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07326791B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-a42c2b09bf6e4ab2bbd83a9976bd2cb0 |
| Source note | uspto-grants-2008_02 |