HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → HCID 178523883, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | 3-Bromo-4-(2,5-dihydropyrrol-1-ylcarbonyl)benzoic acid | HCID 69309865 | — |
| Reactant | Bromine chlorine | HCID 131726752 | — |
| Reactant | (1R)-1-(5-bromo-1H-benzimidazol-2-yl)-2-hydroxyethylamine | HCID 178511832 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 178523883 | HCID 178523883 | 57% |
Reaction Steps
Prepared analogously to Example 1g from 3-bromo-4-(2,5-dihydropyrrol-1-ylcarbonyl)benzoic acid, TBTU, diisopropylethylamine, and (1R)-1-(5-bromo-1H-benzimidazol-2-yl)-2-hydroxyethylamine in tetrahydrofuran. Yield: 57%; melting point: 124° C.-126° C.; C21H18BrClN4O3 (489.76); mass spectrum: (M+H)+=489/491/493 (bromine/chlorine isotope).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07326791B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-84d5f502de794f1084e9d6e0d1468bb6 |
| Source note | uspto-grants-2008_02 |