HuagongsheHuagongshe Chemistry Print Report · For research reference only
Bromine → HCID 178523882, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Bromine | HCID 24408 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | 3-Bromo-4-(pyrrolidin-1-ylcarbonyl)benzoic acid | HCID 69312488 | — |
| Reactant | (1R)-1-(5-bromo-1H-benzimidazol-2-yl)-2-hydroxyethylamine | HCID 178511832 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | Dichloromethane ethanol | HCID 21584144 | — |
| Product | HCID 178523882 | HCID 178523882 | 50% |
Reaction Steps
Prepared analogously to Example 1g from 3-bromo-4-(pyrrolidin-1-ylcarbonyl)benzoic acid, TBTU, diisopropylethylamine, and (1R)-1-(5-bromo-1H-benzimidazol-2-yl)-2-hydroxyethylamine in tetrahydrofuran. Yield: 50%; melting point: 114° C.-116° C.; Rf value: 0.25 (silica gel: dichloromethane/ethanol=95:5); C21H20Br2N4O3 (536.22); mass spectrum: (M+H)+=535/537/539 (bromine isotope).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07326791B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-4530c19009854171952de0037de6b12b |
| Source note | uspto-grants-2008_02 |