Tetrahydrofuran → HCID 23104489, compound

Participants

Reaction Conditions

Reaction Steps

0.3 g of 4-fluoronitrobenzene, 0.413 g of 3-amino-5-methylpyrazole, and 0.286 g of potassium tert-butoxide were added to a solution of 2.5 ml of THF. The reaction medium was heated at 60° C. for 7 hours and, after cooling to room temperature, was then poured into a water and ice mixture. The yellow precipitate formed was filtered off, reslurried in water and then dried over P2O5. 0.361 g of 5-methyl-N-(4-nitrophenyl)-1H-pyrazol-3-amine (1) was obtained.

Provenance & Evidence