4-Tert-Butylaniline → HCID 11304276, compound

Participants

Reaction Steps

1-Chloro-6-(3-methyl-2-pyridinyl)phthalazine (200 mg; 0.78 mmol) and 4-tert-butylaniline (117 mg, 0.125 mL; 0.78 mmol) in 1,4-dioxane were heated at reflux for 2 h. After allowing to cool down to room temperature the precipitate was collected by filtration washed with 1,4-dioxane and dried to give the title compound (135 mg) (43%). 1H NMR (500 MHz, DMSO-d6) δ: 1.35 (9H, s), 7.48 (1H, dd, J 4.9 and 7.6 Hz), 7.55-7.61 (4H, m), 7.90 (1H, dd, J 0.8 and 7.8 Hz), 8.47 (1H, dd, J 1.6 and 8.6 Hz), 8.52 (1H, d, J 2.0 Hz), 8.63 (1H, dd, J 1.2 and 4.7 Hz), 9.09 (1H, d, J 8.6), 9.32 (1H, s); MS (ES M+1) 369.

Provenance & Evidence