関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | 1-(3-Methylanilino)-4-([1,3,5]trioxan-2-yl)phthalazine | HCID 22386460 | — |
| 溶媒 | Sulfuric Acid | HCID 1118 | — |
| 生成物 | 1-(3-Methylanilino)phthalazine-4-carbaldehyde | HCID 22386453 | — |
反応手順
A suspension of 3.15 g (9.74 mmol) 1-(3-methylanilino)-4-([1,3,5]trioxan-2-yl)phthalazine in 150 ml H2SO4 (10% in H2O) is stirred for 7 h at 100° C. The suspension is cooled to RT and adjusted to alkaline pH with NaOH (20% in H2O), the title compound that precipitates out is filtered off and washed with water, 1H-NMR (DMSO-d6) 10.17 (s, HCO), 9.84 (s, HN), 9.02 (d, 1H), 8.67 (d, 1H), 8.03 (m, 2H), 7.8-7.6 (2 sb, 2H), 7.30 (t, 1H), 6.98 (d, 1H), 2.36 (s, 3H); FAB-MS (M−H)+=262.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07329660B2 |
|---|
| 出典データセット | uspto-grants-2008_02 |
|---|
| ORD ID | ord-2d2a93437c2a4435bf1934021759c99d |
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| 出典メモ | uspto-grants-2008_02 |
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