Ammonia → HCID 22386466, compound

Participants

Reaction Conditions

Reaction Steps

Under N2-atmosphere, 217 mg (0.818 mmol) 4-[2-(6-methylpyridin-3-yl)ethyl]phthalazin-1(2H)-one in 3.3 ml acetonitrile is mixed with 187 μl (2.04 mmol) phosphoryl chloride and 0.41 ml 4 N HCl in dioxane and stirred for 9 h at 60° C. After cooling to RT, 2.6 ml H2O, followed by a solution of 0.5 ml sat. NH3 and 5 ml H2O is added. Immediate extraction with 3 portions of EtOAc, washing of the organic layers with water and brine, drying (Na2SO4) and evaporation yield the title compound; FAB-MS (M+H)+=284.

Provenance & Evidence