Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4,4,4-Trifluoro-1-(4-fluorophenyl)butane-1,3-dione → 5-(4-Fluorophenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carbonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4,4,4-Trifluoro-1-(4-fluorophenyl)butane-1,3-dione | HCID 2771476 | — |
| 반응물 | HCID 178510443 | HCID 178510443 | — |
| 생성물 | 5-(4-Fluorophenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carbonitrile | HCID 4766304 | 39% |
반응 단계
Reaction of 1-(4-fluoro-phenyl)-4,4,4-trifluoro-butane-1,3-dione (234 mg, 1.0 mmol), prepared from commercially available 4-fluoro-acetophenone according to general procedure A, and 3-amino-4-cyano-pyrazole (108 mg, 1.0 mmol) according to general procedure B yielded the title compound as a yellow solid (118 mg, 39%). MS (ISP) 306.9 [(M+H)+]; mp 198° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07329662B2 |
| 출처 데이터셋 | uspto-grants-2008_02 |
| ORD ID | ord-e4ab1d9700334fd784f7a1528cafec66 |
| 출처 메모 | uspto-grants-2008_02 |