1-(2,4-Difluorophenyl)-4,4,4-trifluorobutane-1,3-dione → HCID 67213362, compound

HRID 2054222Notes

Reaction equation

HRID 2054222 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9](=O)[CH2:10][C:11](=O)[C:12]([F:15])([F:14])[F:13].[NH2:18][C:19]1[C:23]([C:24]#[N:25])=[CH:22][NH:21][N:20]=1>>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[CH:10]=[C:11]([C:12]([F:15])([F:14])[F:13])[N:20]2[N:21]=[CH:22][C:23]([C:24]#[N:25])=[C:19]2[N:18]=1

Participants

3

Reactant 2

HCID 136109321-(2,4-Difluorophenyl)-4,4,4-trifluorobutane-1,3-dioneHCID 178510443HCID 178510443, compound

Product 1

HCID 67213362HCID 67213362, compoundYield 22.2%

Procedure

Reaction of 1-(2,4-difluoro-phenyl)-4,4,4-trifluoro-butane-1,3-dione (252 mg, 1.0 mmol), prepared from commercially available 2,4-difluoro-acetophenone according to general procedure A, and 3-amino-4-cyano-pyrazole (108 mg, 1.0 mmol) according to general procedure B yielded the title compound as a light yellow solid (72 mg, 22%). MS (ISP) 325.0 [(M+H)+]; mp 149° C.

Sources & evidence

ORD record
ord-548fda8c46c247f69a5419febfc3b3c3
Source dataset
uspto-grants-2008_02
Patent number
US07329662B2

Reaction notes

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