HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(3-Chloro-4-fluorophenyl)-4,4,4-trifluorobutane-1,3-dione → 5-(3-Chloro-4-fluoro-phenyl)-7-trifluoromethyl-pyrazolo[1,5-a]pyrimidine-3-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(3-Chloro-4-fluorophenyl)-4,4,4-trifluorobutane-1,3-dione | HCID 12921697 | — |
| Reactant | HCID 178510443 | HCID 178510443 | — |
| Product | 5-(3-Chloro-4-fluoro-phenyl)-7-trifluoromethyl-pyrazolo[1,5-a]pyrimidine-3-carbonitrile | HCID 11313825 | 32% |
Reaction Steps
Reaction of 1-(3-chloro-4-fluoro-phenyl)-4,4,4-trifluoro-butane-1,3-dione (269 mg, 1.0 mmol), prepared from commercially available 3-chloro-4-fluoro-acetophenone according to general procedure A, and 3-amino-4-cyano-pyrazole (108 mg, 1.0 mmol) according to general procedure B yielded the title compound as an off-white solid (109 mg, 32%). MS (ISP) 341.0 [(M+H)+]; mp 190° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07329662B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-1514371519354511b725edeb422fed9e |
| Source note | uspto-grants-2008_02 |