HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Acetylpyridine → 5-Pyridin-4-yl-7-trifluoromethyl-pyrazolo[1,5-a]pyrimidine-3-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Acetylpyridine | HCID 14282 | — |
| Reactant | 4,4,4-Trifluoro-1-(pyridin-4-yl)butane-1,3-dione | HCID 238298 | — |
| Reactant | HCID 178510443 | HCID 178510443 | — |
| Product | 5-Pyridin-4-yl-7-trifluoromethyl-pyrazolo[1,5-a]pyrimidine-3-carbonitrile | HCID 50852849 | 38% |
Reaction Steps
Reaction of 1-pyridin-4-yl-4,4,4-trifluoro-butane-1,3-dione (217 mg, 1.0 mmol), prepared from commercially available 4-acetylpyridine according to general procedure A, and 3-amino-4-cyano-pyrazole (108 mg, 1.0 mmol) according to general procedure B yielded the title compound as a light yellow solid (110 mg, 38%). MS (ISP) 289.8 [(M+H)+]; mp 233° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07329662B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-d2996406277542b783b247344967c9b0 |
| Source note | uspto-grants-2008_02 |