HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Amino-4-cyano-5-cyanomethylpyrazole → 5-(3-Chloro-4-fluoro-phenyl)-2-cyanomethyl-7-trifluoromethyl-pyrazolo[1,5-a]pyrimidine-3-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Amino-4-cyano-5-cyanomethylpyrazole | HCID 95185 | — |
| Reactant | 1-(3-Chloro-4-fluorophenyl)-4,4,4-trifluorobutane-1,3-dione | HCID 12921697 | — |
| Product | 5-(3-Chloro-4-fluoro-phenyl)-2-cyanomethyl-7-trifluoromethyl-pyrazolo[1,5-a]pyrimidine-3-carbonitrile | HCID 67213371 | 59% |
Reaction Steps
Reaction of 1-(3-chloro-4-fluoro-phenyl)-4,4,4-trifluoro-butane-1,3-dione (269 mg, 1.0 mmol), prepared from commercially available 3-chloro-4-fluoro-acetophenone according to general procedure A, and commercially available 3-amino-4-cyano-5-cyanomethyl-pyrazole (147 mg, 1.0 mmol) according to general procedure B yielded the title compound as a light yellow solid (223 mg, 59%). MS (ISP) 380.1 [(M+H)+]; mp 185° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07329662B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-5d92adc12d1945a48b342f28c486d591 |
| Source note | uspto-grants-2008_02 |