1,3-Butanedione, 1-(4-chloro-3-methylphenyl)-4,4,4-trifluoro- → HCID 67213202、化合物

HRID 2054241ノート

反応式

HRID 2054241 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=O)[CH2:9][C:10](=O)[C:11]([F:14])([F:13])[F:12])=[CH:4][C:3]=1[CH3:17].[NH2:18][C:19]1[C:23]([C:24]2[CH:25]=[N:26][CH:27]=[CH:28][CH:29]=2)=[CH:22][NH:21][N:20]=1>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]([C:11]([F:14])([F:13])[F:12])[N:20]3[N:21]=[CH:22][C:23]([C:24]4[CH:25]=[N:26][CH:27]=[CH:28][CH:29]=4)=[C:19]3[N:18]=2)=[CH:4][C:3]=1[CH3:17]

参加物

3

反応物 2

HCID 670009781,3-Butanedione, 1-(4-chloro-3-methylphenyl)-4,4,4-trifluoro-HCID 178509255HCID 178509255、化合物

生成物 1

HCID 67213202HCID 67213202、化合物収率 70.5%

実験手順

Reaction of 1-(4-chloro-3-methyl-phenyl)-4,4,4-trifluoro-butane-1,3-dione (265 mg, 1.0 mmol), prepared from commercially available 4-chloro-3-methyl-acetophenone according to general procedure A, and 3-amino-4-(3-pyridinyl)-pyrazole [CAS No. 40545-68-2; prepared from 3-cyanomethyl-pyridine as described in Bioorg. Med. Chem. Lett. 12 (2002) 3537-3541] (160 mg, 1.0 mmol) according to general procedure B yielded the title compound as a yellow solid (274 mg, 70%). MS (ISP) 375.3 [(M+H)+]; mp 193° C.

出典と根拠

ORDレコード
ord-abbdb45943f54514bf85601c325420ea
出典データセット
uspto-grants-2008_02
特許番号
US07329662B2

反応ノート

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