Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HCID 12921697, 화합물 → 5-(3-Chloro-4-fluoro-phenyl)-3-pyridin-2-yl-7-trifluoromethyl-pyrazolo[1,5-a]pyrimidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | HCID 12921697 | HCID 12921697 | — |
| 반응물 | HCID 178509250 | HCID 178509250 | — |
| 생성물 | 5-(3-Chloro-4-fluoro-phenyl)-3-pyridin-2-yl-7-trifluoromethyl-pyrazolo[1,5-a]pyrimidine | HCID 67213331 | 71% |
반응 단계
Reaction of 1-(3-chloro-4-fluoro-phenyl)-4,4,4-trifluoro-butane-1,3-dione (269 mg, 1.0 mmol), prepared from commercially available 3-chloro-4-fluoro-acetophenone according to general procedure A, and 3-amino-4-(2-pyridinyl)-pyrazole [CAS No. 493038-87-2; prepared from 2-cyanomethyl-pyridine as described in Bioorg. Med. Chem. Lett. 12 (2002) 3537-3541] (160 mg, 1.0 mmol) according to general procedure B yielded the title compound as a yellow solid (279 mg, 71%). MS (ISP) 393.1 [(M+H)+]; mp 197° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07329662B2 |
| 출처 데이터셋 | uspto-grants-2008_02 |
| ORD ID | ord-2fb1adc5c6be4c8681a8989f9e38b9b3 |
| 출처 메모 | uspto-grants-2008_02 |