2-Chloroacetophenone → HCID 67213026, compound

HRID 2054300Notes

Reaction equation

[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8](=O)[CH2:9][C:10](=O)[C:11]([F:14])([F:13])[F:12].ClCC(C1C=CC=CC=1)=O.[NH2:27][C:28]1[N:29]=[CH:30][NH:31][C:32]=1[C:33]#[N:34]>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[CH:9]=[C:10]([C:11]([F:14])([F:13])[F:12])[N:29]2[CH:30]=[N:31][C:32]([C:33]#[N:34])=[C:28]2[N:27]=1

Participants

Reactant 3

HCID 107572-Chloroacetophenone

HCID 787775-amino-1H-imidazole-4-carbonitrile

HCID 157720221-(2-Chlorophenyl)-4,4,4-trifluorobutane-1,3-dione

Product 1

HCID 67213026HCID 67213026, compoundYield 17%

Procedure

Reaction of 1-(2-chloro-phenyl)-4,4,4-trifluoro-butane-1,3-dione (251 mg, 1.0 mmol), prepared from commercially available 2-chloro-acetophenone according to general procedure A, and 4-amino-5-cyano-1H-imidazole (108 mg, 1.0 mmol) according to general procedure B yielded the title compound as a yellow solid (55 mg, 17%). MS (ISP) 323.1 [(M+H)+]; mp 180° C.

Sources & evidence

ORD record: ord-8cc01d99689548a4a1a08b7cce8a3def
Source dataset: uspto-grants-2008_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07329662B2

Reaction notes

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