Ammonium formate → HCID 11219535, compound

Participants

Reaction Steps

Into a solution of 2.30 g (6.33 mmol) of 4-isopropyl-3-(1-benzylpiperidin-4-yl)-3,4-dihydro-2(1H)-quinazolinone in 127 ml of methanol, 0.23 g (0.11 mmol) of 10% palladium carbon (50% wet) and 1.60 g (25.3 mmol) of ammonium formate were added and refluxed under stirring and heating for 4 hours. After cooling to room temperature, the reaction mixture was filtered. To the filtrate, 0.5% aqueous sodium hydroxide solution and chloroform were added and stirred. The separated oil layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure. The concentrated residue was purified by silica gel column chromatography (chloroform/methanol/triethylamine 90/10/5) to give 1.73 g (6.33 mmol) of the above-titled compound.

Provenance & Evidence