Ethanol → HCID 11379978, compound

Participants

Reaction Steps

To a solution of 2-[2-Phthalimido-1-(2,3,5,6-tetrahydropyran-2-yl)oxyethyl]-7-azaindole (10.2 g, 26 mmol) in EtOH (630 ml) NH2NH2.H2O (1.53 ml, 31 mmol) was added. The mixture was refluxed for 3 h. The solvent was evaporated, the residue dissolved in CH2Cl2 and washed with saturated aq. NaHCO3. The aqueous layer was extracted three times with CH2Cl2. The organic solutions were evaporated together to obtain a diastereomeric mixture (1:1) of 9a (6.72 g, 100%) as a light orange solid.

Provenance & Evidence