HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → HCID 11267094, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Triphosgene | HCID 94429 | — |
| Reactant | HCID 11185412 | HCID 11185412 | — |
| Reactant | HCID 11346726 | HCID 11346726 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 11267094 | HCID 11267094 | 63% |
Reaction Steps
Following the same procedure as for 10a, from triphosgene (20 mg, 0.07 mmol) in CH2Cl2 (3 ml), 9b (58 mg, 0.20 mmol) and DIPEA (34 μl, 0.20 mmol) in CH2Cl2 (3 ml). Reaction time 30 min. at room temperature. The crude mixture was purified by flash column chromatography. Elution with CH2Cl2/MeOH (98/2) gave a diastereomeric mixture (1:1) of 10b (40 g, 63%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07329666B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-4a5e3db53ad146169284e51616ce9d90 |
| Source note | uspto-grants-2008_02 |