HCID 11346726, compound → HCID 21575571, compound

HRID 2054348Notes

Reaction equation

HRID 2054348 reaction equation
O1CCCCC1[O:7][CH:8]1[CH2:13][NH:12][C:11](=[O:14])[N:10]2[C:15]3[N:21]=[CH:20][CH:19]=[CH:18][C:16]=3[CH:17]=[C:9]12>C(Cl)Cl>[OH:7][CH:8]1[CH2:13][NH:12][C:11](=[O:14])[N:10]2[C:15]3[N:21]=[CH:20][CH:19]=[CH:18][C:16]=3[CH:17]=[C:9]12

Participants

3

Reactant 1

HCID 11346726HCID 11346726, compound

Product 1

HCID 21575571HCID 21575571, compoundYield 117.2%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 10a (6 g, 21 mmol) in CH2Cl2 (400 ml) 4N aq. HCl (400 ml) was added. After 45 min. stirring at room temperature the two layers were separated. The organic solution was extracted with 4N aq. HCl. The aqueous solution was filtered and evaporated to obtain 6,7,8,9-Tetrahydro-6-hydroxypyrido[3′,2′:4,5]pyrrolo[1,2-c]pyrimidin-9one (5 g, 100%) as hydrochloride salt as a light orange solid.

Workup

  1. customwere separated
  2. extractionThe organic solution was extracted with 4N aq. HCl
  3. filtrationThe aqueous solution was filtered
  4. customevaporated

Sources & evidence

ORD record
ord-d2343f82b93c42cc83abb6f8ef520217
Source dataset
uspto-grants-2008_02
Patent number
US07329666B2

Reaction notes

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