HCID 11267094, compound → HCID 11436218, compound

HRID 2054349Notes

Reaction equation

HRID 2054349 reaction equation
O1CCCCC1[O:7][CH:8]1[CH2:13][NH:12][C:11](=[O:14])[N:10]2[C:15]3[N:21]=[CH:20][CH:19]=[C:18]([O:22][CH3:23])[C:16]=3[CH:17]=[C:9]12>C(Cl)Cl>[OH:7][CH:8]1[CH2:13][NH:12][C:11](=[O:14])[N:10]2[C:15]3[N:21]=[CH:20][CH:19]=[C:18]([O:22][CH3:23])[C:16]=3[CH:17]=[C:9]12

Participants

3

Reactant 1

HCID 11267094HCID 11267094, compound

Product 1

HCID 11436218HCID 11436218, compoundYield 107.2%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 10b (25 mg, 0.08 mmol) in CH2Cl2 (5 ml) 4N aq. HCl (5 ml) was added and the mixture was stirred at room temperature for 45 min. The organic solution was separated and extracted with 4N aq. HCl. The aqueous solution was filtered and evaporated to obtain 6,7,8,9-Tetrahydro-6-hydroxy-4-methoxypyrido[3′,2′:4,5]pyrrolo[1,2-c]pyrimidin-9-one (20 mg, 95%) as hydrochloride salt as a light orange solid.

Workup

  1. customThe organic solution was separated
  2. extractionextracted with 4N aq. HCl
  3. filtrationThe aqueous solution was filtered
  4. customevaporated

Sources & evidence

ORD record
ord-c9a713a00c0847c8bc81012b9a1cad27
Source dataset
uspto-grants-2008_02
Patent number
US07329666B2

Reaction notes

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