N-Iodosuccinimide → HCID 11269050, compound

HRID 2054354Notes

Reaction equation

HRID 2054354 reaction equation
C1C(=O)N([I:8])C(=O)C1.[C:9]([NH:12][C:13]1[N:18]2[C:19]3[N:25]=[CH:24][CH:23]=[C:22]([O:26][CH3:27])[C:20]=3[CH:21]=[C:17]2[CH:16]=[CH:15][N:14]=1)(=[O:11])[CH3:10]>C(Cl)Cl>[C:9]([NH:12][C:13]1[N:18]2[C:19]3[N:25]=[CH:24][CH:23]=[C:22]([O:26][CH3:27])[C:20]=3[C:21]([I:8])=[C:17]2[CH:16]=[CH:15][N:14]=1)(=[O:11])[CH3:10]

Participants

4

Reactant 2

HCID 120273N-IodosuccinimideHCID 21575575HCID 21575575, compound

Product 1

HCID 11269050HCID 11269050, compoundYield 93%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

NIS (18 mg, 0.078 mmol) was portionwise added to a cooled (0° C.) solution of 9-Acetylamino-4-methoxypyrido[3′,2′:4,5]pyrrolo[1,2-c]pyrimidine (20 mg, 0.078 mmol) in CH2Cl2 (15 ml). The mixture was stirred for 15 min. The solution was diluted with CH2Cl2 (50 ml) and washed twice with water. The organic layer was dried and evaporated to obtain 20b (27 mg, 93%).

Workup

  1. washwashed twice with water
  2. customThe organic layer was dried
  3. customevaporated

Sources & evidence

ORD record
ord-525c301f94cc48f08a109b10244c7411
Source dataset
uspto-grants-2008_02
Patent number
US07329666B2

Reaction notes

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