Acetic Anhydride → HCID 59655846, compound

Participants

Reaction Steps

A mixture of 3-aminomethyl-4-fluoro-1-trimethylstannylbenzene (505.4 mg, 1.76 mmol), Ac2O (215.3 μL, 2.28 mmol) and NEt3 (489 μL, 3.51 mmol) was stirred at room temperature in CH2Cl2 (18 mL). After 3 h, extractive EtOAc/H2O workup followed by flash chromatography (EtOAc/Hexanes, 40:60) provided the title compound (422 mg, 73%) as an oil. 1H NMR (DMSO, 400 MHz): 8.29 (br s, 1H), 7.41 (d, J=7.52 Hz, 1H), 7.45-7.30 (m, 1H), 7.14 (dd, J=10.9, 8.2 Hz, 1H), 4.27 (d, J=5.47 Hz, 2H), 1.85 (s, 3H), 0.26 (s, 9H).

Provenance & Evidence