HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 59655926, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Methanesulfonyl chloride | HCID 31297 | — |
| Reactant | Water ethylacetate | HCID 22728543 | — |
| Reactant | HCID 59655900 | HCID 59655900 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 59655926 | HCID 59655926 | 53.1% |
Reaction Steps
A mixture of 3-aminomethyl-4-fluoro-1-trimethylstannylbenzene (507.9 mg, 1.76 mmol), ClSO2Me (180.9 μL, 2.29 mmol) and NEt3 (492 μL, 3.52 mmol) was stirred at room temperature in CH2Cl2 (18 mL). After 3 h, extractive EtOAc/H2O workup followed by flash chromatography (EtOAc/Hexanes, 20:80) provided the title compound (342 mg, 53%) as an oil. 1H NMR (CDCl3, 400 MHz.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07329668B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-0a0dcc4400ae49d49ae378404cd49edd |
| Source note | uspto-grants-2008_02 |