反应详情

温度

60 °C

Acetic anhydride (38.9 mL, 412 mmol) was added to a stirred solution of 3,4-dimethylaniline 1-5 (10.0 g, 82.5 mmol) in pyridine (150 mL) at ambient temperature. After stirring at approximately 60° C. for 2 h, the volatiles were removed in vacuo, and the residue was partitioned between diethyl ether and aqueous 1 N hydrochloric acid. The organic phase was separated and washed with saturated aqueous sodium bicarbonate, brine, dried (sodium sulfate) and concentrated in vacuo to afford 1-6 as a white crystalline solid.

1. customthe volatiles were removed in vacuo
2. customthe residue was partitioned between diethyl ether and aqueous 1 N hydrochloric acid
3. customThe organic phase was separated
4. washwashed with saturated aqueous sodium bicarbonate, brine
5. dry with materialdried (sodium sulfate)
6. concentrationconcentrated in vacuo