3,4-diaminobenzenesulfonamide → HCID 10068962, compound

Participants

Reaction Conditions

Reaction Steps

3-(6-amino-5-formylpyridin-3-yl)benzonitrile (0.06 g, 0.27 mmol), 3,4-diaminobenzene-1-sulphonamide (0.050 g, 0.27 mmol), and NaHSO3 (0.029, 0.40 mmol) were combined in 2 mL of dimethylacetamide and heated to 200° C. in the SmithSynthesizer™ microwave instrument for 10 minutes. Upon cooling, the solvent was removed and the residue was chromatographed on silica gel eluting with hexanes/ethyl acetate (0 to 100% EtOAc over 10 minutes) to afford 2-[2-amino-5-(3-cyanophenyl)pyridin-3-yl]-1H-benzimidazole-6-sulfonamide (0.046 g) as a solid.

Provenance & Evidence