4-Fluorophenylboronic acid → HCID 10249370, compound

HRID 2054467Notes

Reaction equation

HRID 2054467 reaction equation
[NH2:1][C:2]1[C:7]([CH:8]=[O:9])=[CH:6][C:5]([C:10]2[CH:15]=[CH:14][C:13]([F:16])=[CH:12][CH:11]=2)=[CH:4][N:3]=1.[NH2:17][C:18]1[CH:19]=[C:20]([S:25]([NH2:28])(=[O:27])=[O:26])[CH:21]=[CH:22][C:23]=1[NH2:24].FC1C=CC(B(O)O)=CC=1>>[NH2:1][C:2]1[C:7]([C:8]2[NH:17][C:18]3[CH:19]=[C:20]([S:25]([NH2:28])(=[O:26])=[O:27])[CH:21]=[CH:22][C:23]=3[N:24]=2)=[CH:6][C:5]([C:10]2[CH:15]=[CH:14][C:13]([F:16])=[CH:12][CH:11]=2)=[CH:4][N:3]=1.[NH2:1][C:2]1[C:7]([CH:8]=[O:9])=[CH:6][C:5]([C:10]2[CH:15]=[CH:14][C:13]([F:16])=[CH:12][CH:11]=2)=[CH:4][N:3]=1

Participants

5

Reactant 3

HCID 2856454-Fluorophenylboronic acidHCID 27359273,4-diaminobenzenesulfonamideHCID 58668625HCID 58668625, compound

Product 2

HCID 10249370HCID 10249370, compoundHCID 58668625HCID 58668625, compound

Procedure

The title compound was synthesized using the procedure of step (c) in Example 13 except that 2-amino-5-(4-fluorophenyl)pyridin-3-carboxaldehyde and 3,4-diaminobenzene-1-sulfonamide were utilized. The 2-amino-5-(4-fluorophenyl)pyridin-3-carboxaldehyde was synthesized according to step (b) of example 13, using 4-fluorophenylboronic acid.

Sources & evidence

ORD record
ord-b2ffca0ae14c43be8dd56b43fdc4320a
Source dataset
uspto-grants-2008_02
Patent number
US07329678B2

Reaction notes

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