HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 1,1-Dimethylethyl [(2R)-2-hydroxy-2-phenylethyl]carbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | (R)-(-)-2-Amino-1-phenylethanol | HCID 6951165 | — |
| Reactant | Carbonic acid, bis(1,1-dimethylethyl) ester | HCID 10219638 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 1,1-Dimethylethyl [(2R)-2-hydroxy-2-phenylethyl]carbamate | HCID 11481792 | 88.4% |
Reaction Steps
(R)-α-(Aminomethyl)benzenemethanol (1.70 g) and bis(1,1-dimethylethyl)carbonate (2.98 g) were dissolved in methanol (20 ml) and triethylamine (4.3 ml) added. The mixture was stirred at room temperature for 4 days and then concentrated to leave the sub-title compound as an oil (2.60 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07329686B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-d00a954de056464b938d25d7f2aca14b |
| Source note | uspto-grants-2008_02 |