Sodium Hydroxide → HCID 59656081, compound

HRID 2054557Notes

Reaction equation

HRID 2054557 reaction equation
[C:1]12([C:11]3[N:15]([CH2:16][C:17]([O:19]C)=[O:18])[C:14]([C:21]4[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=4)=[N:13][N:12]=3)[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2.[OH-].[Na+]>CO>[C:1]12([C:11]3[N:15]([CH2:16][C:17]([OH:19])=[O:18])[C:14]([C:21]4[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=4)=[N:13][N:12]=3)[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 59655998HCID 59655998, compound

Product 1

HCID 59656081HCID 59656081, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Methyl [3-(1-adamantyl)-5-phenyl-4H-1,2,4-triazol-4-yl]acetate (4-55) (15 mg), 0.5 N NaOH (1 mL) and methanol (0.5 mL) were reacted at room temperature for 17 h. The methanol was evaporated in vacuo. The aqueous residue was acidified with acetic acid and extracted ten times with chloroform. The extracts were dried (MgSO4) and evaporated in vacuo to give [3-(1-adamantyl)-5-phenyl-4H-1,2,4-triazol-4-yl]acetic acid (4-54). MS: 338 (M+1).

Workup

  1. customThe methanol was evaporated in vacuo
  2. extractionextracted ten times with chloroform
  3. dry with materialThe extracts were dried (MgSO4)
  4. customevaporated in vacuo

Sources & evidence

ORD record
ord-ac11a4c7617f49f799b009b45daccc00
Source dataset
uspto-grants-2008_02
Patent number
US07329683B2

Reaction notes

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