HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2054587Generated: October 30, 2026
Potassium Carbonate → 1-benzyl-5-(4-dibenzofuran-4-yl-phenyl)-3-nitro-1H-pyridin-2-one
https://huagongshe.com/reaction/2054587
Participants
| Role | Name | HCID | Charge |
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| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1-benzyl-5-bromo-3-nitro-1H-pyridin-2-one | HCID 59655962 | — |
| Reactant | (4-(Dibenzo[b,d]furan-4-yl)phenyl)boronic acid | HCID 59655966 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 1-benzyl-5-(4-dibenzofuran-4-yl-phenyl)-3-nitro-1H-pyridin-2-one | HCID 59655956 | 99.9% |
Reaction Steps
A solution of 1-benzyl-5-bromo-3-nitro-1H-pyridin-2-one (1.0 g, 3.24 mmol), 4-dibenzofuran-4-yl-phenyl-boronic acid (932 mg, 3.24 mmol), K2CO3 (1.34 g, 3 equiv., 9.7 mmol) in toluene (15 mL), ethanol (10 mL) and water (5 mL) was treated with treated with Pd(PPh3)4 (125 mg). After heating to 80° C. overnight, the solution was cooled to room temperature and the resulting solids were filtered and washed with ether (2×6 mL) to give 1-benzyl-5-(4-dibenzofuran-4-yl-phenyl)-3-nitro-1H-pyridin-2-one as a yellow solid (1.53 g, 92%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07329680B2 |
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| Source dataset | uspto-grants-2008_02 |
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| ORD ID | ord-058a88e42ad747cf89e27b4a7eacd22b |
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| Source note | uspto-grants-2008_02 |
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