反应详情

1-benzyl-5-(4-dibenzofuran-4-yl-phenyl)-3-nitro-1H-pyridin-2-one (100 mg, 0.212 mmol) was dissolved in hot 50% ethanol in DMF (8 mL) and cooled to room temperature. 10% Pd—C (10 mg) was added and the solution was shaken on a Parr hydrogenator with 60 psi H2 for 2 h. The resulting mixture was diluted with water (30 mL) and ethyl acetate (70 mL), separated and extracted with ethyl acetate (100 mL). The combined organic layers were washed with sat'd aq NaCl, dried over anhydrous MgSO4, filtered and concentrated in vacuo to give 3-amino-1-benzyl-5-(4-dibenzofuran-4-yl-phenyl)-1H-pyridin-2-one as a yellow sold that was used without further purification.

1. customseparated
2. extractionextracted with ethyl acetate (100 mL)
3. washThe combined organic layers were washed with sat'd aq NaCl
4. dry with materialdried over anhydrous MgSO4
5. filtrationfiltered
6. concentrationconcentrated in vacuo