HCID 11462285, compound → HCID 69298124, compound

Participants

Reaction Steps

Arylation of 4-(5-chloro-1H-indol-3-yl)-4-oxo-butyric acid 2-trimethylsilanyl-ethyl ester with 1-(4-chloro-6-cyclopentyloxy-[1,3,5]-triazin-2-yl)-1,2,3,4-tetrahydro-quinoline and subsequent hydrolysis as outlined previously yielded the titled compound. Rf 0.30 (5% methanol in dichloromethane); 1H NMR (DMSO-d6, 300 MHz) δ 8.97 (1H, s, ArH), 8.55 (1H, d, J=9 Hz, ArH), 8.18 (1H, d, J=2 Hz, ArH), 7.81 (1H, d, J=8 Hz, ArH), 7.35-7.10 (4H, m, ArH), 5.44 (1H, m, CH), 4.08 (2H, t, J=6 Hz, CH2), 3.22 (2H, t, J=6 Hz, CH2), 2.78 (2H, t, J=6 Hz, CH2), 2.58 (2H, t, J=6 Hz, CH2), 2.01-1.61 (10H, m, CH2); ESI-LCMS e/z calculated for C29H28ClN5O4 545.183, found 546 (M+H)+, 568 (M+Na)+.

Provenance & Evidence