HCID 11462285, compound → HCID 59655980, compound

Participants

Reaction Steps

Arylation of 4-(5-chloro-1H-indol-3-yl)-4-oxo-butyric acid 2-trimethylsilanyl-ethyl ester with 1-(4-chloro-6-phenyl-[1,3,5]-triazin-2-yl)-1,2,3,4-tetrahydro-quinoline and subsequent hydrolysis as outlined previously yielded the titled compound. Rf 0.34 (5% methanol in dichloromethane); 1H NMR (THF-d8, 300 MHz) δ 9.21 (1H, s, ArH), 8.72 (1H, m, ArH), 8.59 (2H, d, J=7 Hz, ArH), 8.39 (1H, d, J=2 Hz, ArH), 7.95 (1H, d, J=8 Hz, ArH), 7.62-7.51 (3H, m, ArH), 7.35-7.15 (4H, m, ArH), 4.32 (2H, t, J=6 Hz, CH2), 3.30 (2H, t, J=7 Hz, CH2), 2.88 (2H, t, J=6 Hz, CH2), 2.72 (2H, t, J=7 Hz, CH2), 2.13 (2H, m, CH2); ESI-LCMS e/z calculated for C30H24ClN5O3 537.157, found 538 (M+H)+, 560 (M+Na)+.

Provenance & Evidence