Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Thionyl Chloride → {4-[2-(4-Fluoro-phenyl)ethyl]piperazin-1-yl}isoquinolin-3-ylmethanone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Thionyl Chloride | HCID 24386 | — |
| 반응물 | Isoquinoline-3-carboxylic acid | HCID 124656 | — |
| 반응물 | 1-(2-(4-Fluorophenyl)ethyl)piperazine | HCID 11254522 | — |
| 반응물 | Isoquinoline-3-carbonyl chloride | HCID 22064853 | — |
| 생성물 | {4-[2-(4-Fluoro-phenyl)ethyl]piperazin-1-yl}isoquinolin-3-ylmethanone | HCID 44215581 | — |
반응 단계
Analogously to Example 3, firstly isoquinoline-3-carboxylic acid is reacted with thionyl chloride, and the resultant isoquinoline-3-carbonyl chloride is reacted with 1-[2-(4-fluorophenyl)ethyl]piperazine, giving {4-[2-(4-fluoro-phenyl)ethyl]piperazin-1-yl}isoquinolin-3-ylmethanone.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07329749B2 |
| 출처 데이터셋 | uspto-grants-2008_02 |
| ORD ID | ord-12574c840ca043dda608e9a7b995a546 |
| 출처 메모 | uspto-grants-2008_02 |