Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Isopropyl isocyanate | HCID 61277 | — |
| Reactant | HCID 11235229 | HCID 11235229 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 11375343 | HCID 11375343 | — |
Reaction Steps
To a 25° C. solution of N-[4-(piperidin-4-yl sulfamoyl)-naphthalen-1-yl]-benzamide (C-1) in CH2Cl2 was added Et3N followed by 2-isocyanato-propane. The reaction mixture was stirred at 25° C. overnight. Aqueous work-up followed by purification using reverse phase HPLC provided the title compound. 1H NMR (300 MHz, MeOD) δ 8.74 (d, 1H), 8.29 (d, 1H), 8.17 (d, 1H), 8.07 (s, 1H), 8.05 (s, 1H), 7.81 (d, 1H), 7.63 (m, 5H), 3.75 (m, 3H), 3.21 (m, 1H), 2.68 (t, 2H), 1.51 (m, 2H), 1.26 (m, 2H), 1.05 (d, 6H); LC/MS (M+H)+ m/z 495.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07329755B2 |
|---|
| Source dataset | uspto-grants-2008_02 |
|---|
| ORD ID | ord-13d31ce2662947e697fe02c439033e91 |
|---|
| Source note | uspto-grants-2008_02 |
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