P-Anisidine → HCID 16105853, compound

HRID 2054855Notes

Reaction equation

HRID 2054855 reaction equation
COC1C=CC(N)=CC=1.[C:10]([O:14][C:15]([N:17]1[CH2:22][CH2:21][CH:20]([NH:23][S:24]([C:27]2[C:36]3[C:31](=[CH:32][CH:33]=[CH:34][CH:35]=3)[C:30]([N:37]3[C:45](=[O:46])[C:44]4[C:39](=[CH:40][CH:41]=[CH:42][CH:43]=4)[C:38]3=[O:47])=[CH:29][CH:28]=2)(=[O:26])=[O:25])[CH2:19][CH2:18]1)=[O:16])([CH3:13])([CH3:12])[CH3:11].COC1C=CC(NS(C2C3C(=CC=CC=3)C(N3C(=O)C4C(=CC=CC=4)C3=O)=CC=2)(=O)=O)=CC=1>>[C:10]([O:14][C:15]([N:17]1[CH2:18][CH2:19][CH:20]([NH:23][S:24]([C:27]2[C:36]3[C:31](=[CH:32][CH:33]=[CH:34][CH:35]=3)[C:30]([N:37]3[C:45](=[O:46])[C:44]4[C:39](=[CH:40][CH:41]=[CH:42][CH:43]=4)[C:38]3=[O:47])=[CH:29][CH:28]=2)(=[O:25])=[O:26])[CH2:21][CH2:22]1)=[O:16])([CH3:13])([CH3:11])[CH3:12].[C:10]([O:14][C:15]([N:17]1[CH2:22][CH2:21][CH:20]([NH:23][S:24]([C:27]2[C:36]3[C:31](=[CH:32][CH:33]=[CH:34][CH:35]=3)[C:30]([NH2:37])=[CH:29][CH:28]=2)(=[O:26])=[O:25])[CH2:19][CH2:18]1)=[O:16])([CH3:13])([CH3:11])[CH3:12]

Participants

5

Reactant 3

HCID 7732P-AnisidineHCID 5335896HCID 5335896, compoundHCID 16105853HCID 16105853, compound

Product 2

HCID 16105853HCID 16105853, compoundHCID 59656326HCID 59656326, compound

Procedure

4-[4-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-naphthalene-1-sulfonylamino]-piperidine-1-carboxylic acid tert-butyl ester (19) was prepared according to the general procedure in Scheme 3, substituting 4-amino-piperidine-1-carboxylic acid tert-butyl ester for p-anisidine. 4-(4-Amino-naphthalene-1-sulfonylamino)-piperidine-1-carboxylic acid tert-butyl ester (20) was prepared according to the general procedure in Scheme 3 substituting 4-[4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-naphthalene-1-sulfonylamino]-piperidine-1-carboxylic acid tert-butyl ester for 4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-naphthalene-1-sulfonic acid (4-methoxyphenyl)-amide.

Sources & evidence

ORD record
ord-121860fefb364986aba3314d07f9cc54
Source dataset
uspto-grants-2008_02
Patent number
US07329755B2

Reaction notes

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