Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Methanamine, N-methoxy-, hydrochloride (1:1) | HCID 81138 | — |
| Reactant | Carbodiimide | HCID 160435 | — |
| Reactant | HOAt | HCID 181649 | — |
| Reactant | HCID 59656480 | HCID 59656480 | — |
| Solvent | 1,2-Dichloroethane | HCID 11 | — |
| Product | HCID 59656523 | HCID 59656523 | — |
Reaction Steps
To a solution of 4-(1-benzyl-piperidin-4-ylsulfamoyl)-naphthalene-1-carboxylic acid 34 (212 mg, 0.5 mmol) in DCE (5 mL), was added O,N-dimethyl-hydroxylamine hydrochloride (59 ul, 0.6 mmol), PS-carbodiimide (1.9 g, 2.5 mmol), triethyl amine (140 uL, 1 mmol) and HOAt (102 mg, 0.75 mmol). After stirring at 50° C. overnight, the resultant solution was filtered and concentrated in vacuo to give the crude product 4-(1-benzyl-piperidin-4-ylsulfamoyl)-naphthalene-1-carboxylic acid methoxy-methyl-amide 35. LCMS showed m/z: 468 (M+H)+. This material was used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07329755B2 |
|---|
| Source dataset | uspto-grants-2008_02 |
|---|
| ORD ID | ord-b3ec7ee4fba54a4b9bc0bd48e2a8698d |
|---|
| Source note | uspto-grants-2008_02 |
|---|
