Water → HCID 59656698, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of the above benzamide intermediate (1.5 g, 5.0 mmol) in DMF (15 mL) at 0° C. was added cyanuric chloride (0.461 g, 2.5 mmol). The reaction was stirred at 0° C. for 40 min. Water (50 mL) was added and the mixture was extracted with dichloromethane, dried with sodium sulfate and concentrated. Chromatography on silica gel (ether/hexane, 1:1) afforded 4-(N-boc-2-aminoethyl)-2,6-difluorobenzonitrile (1.1 g, 3.9 mmol, 78%).

Provenance & Evidence