反应详情

253 mg (0.53 mmol) of 5-[4-(5-fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethylpentylidenamino]quinoline-2-carboxylic acid amide is dissolved in 10 ml of tetrahydrofuran-methanol (50%) and mixed with 101 mg (2.65 mmol) of sodium borohydride. After 20 hours, the solvent is removed in a vacuum. The subsequent recrystallization of the residue from ethyl acetate-methanol and purification of the mother liquor that is concentrated by evaporation on silica gel with hexane-ethyl acetate (0-50%) yield 116 mg (46% of theory) of the product.

1. customthe solvent is removed in a vacuum
2. customThe subsequent recrystallization of the residue
3. customfrom ethyl acetate-methanol and purification of the mother liquor that
4. concentrationis concentrated by evaporation on silica gel with hexane-ethyl acetate (0-50%) yield 116 mg (46% of theory) of the product