Ammonia → HCID 66525410, compound

HRID 2054958Notes

Reaction equation

HRID 2054958 reaction equation
C[O:2][C:3]([C:5]1[CH:14]=[CH:13][C:12]2[C:7](=[C:8]([NH2:15])[CH:9]=[CH:10][CH:11]=2)[N:6]=1)=O.[NH3:16]>>[NH2:15][C:8]1[CH:9]=[CH:10][CH:11]=[C:12]2[C:7]=1[N:6]=[C:5]([C:3]([NH2:16])=[O:2])[CH:14]=[CH:13]2

Participants

3

Reactant 2

HCID 222AmmoniaHCID 9877675HCID 9877675, compound

Product 1

HCID 66525410HCID 66525410, compound

Procedure

Analogously to Example 37, 120 mg (0.59 mmol) of 8-aminoquinoline-2-carboxylic acid methyl ester is reacted with 10 ml of a 7N methanolic ammonia solution. After purification on silica gel with hexane-ethyl acetate, 79 mg (72% of theory) of the product is obtained.

Workup

  1. customAfter purification on silica gel with hexane-ethyl acetate, 79 mg (72% of theory) of the product
  2. customis obtained

Sources & evidence

ORD record
ord-8fac21c1427f442cb5be96606d65477d
Source dataset
uspto-grants-2008_02
Patent number
US07329753B2

Reaction notes

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